Retinoblastoma Pharmacotherapy; Shahsavari and Mashayekhi
نویسندگان
چکیده
Retinoblastoma is the most common primary intraocular malignancy of infancy and childhood with an incidence of 1 in every 20,000 live births.1 During the 20th century, retinoblastoma was uniformly fatal. Early diagnosis and recent advances in the management of retinoblastoma particularly the use of chemo-therapy have improved the prognosis of this fatal disease. Although this neoplasm has one of the highest cure rates among malignant tumors, it is almost invariably fatal if left un-treated.1 Treatment modalities currently available for retinoblastoma can be classified as follows: (1) focal therapy including cryotherapy, conventional laser photocoagulation, transpupillary thermotherapy, photodynamic therapy (in vitro study), and plaque radiotherapy;2 (2) external beam radiotherapy;3 (3) systemic chemotherapy3 and (4) enucleation. With the advent of chemotherapy, radical methods of management such as enucleation and external beam radiation have been relegated to second and third lines of treatment. Chemotherapy is currently the most important treatment modality for globe salvage in retinoblastoma patients. GENERAL CONSIDERATIONS
منابع مشابه
Pharmacotherapy for Retinoblastoma
Systemic chemotherapy has become the cornerstone of therapy for retinoblastoma. The advent of novel chemotherapeutic and antiangiogenesis agents together with new routes of drug administration including periocular, intravitreal and intra-ophthalmic artery injection will hopefully revolutionize the management of this sight-threatening and potentially fatal infantile ocular neoplasm.
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